Hydrogen Peroxide → 1H-Purine, 8-(2-methoxy-4-(methylsulfinyl)phenyl)-

HRID 1155070ノート

反応式

HRID 1155070 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1.[OH:20]O>FC(F)(F)C(O)=O.O.C(=O)([O-])[O-].[K+].[K+]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([S:9]([CH3:10])=[O:20])[CH:6]=[CH:5][C:4]=1[C:11]1[NH:19][C:18]2[C:13](=[N:14][CH:15]=[N:16][CH:17]=2)[N:12]=1

参加物

6

反応物 2

HCID 784Hydrogen PeroxideHCID 30599131H-Purine, 8-(2-methoxy-4-(methylthio)phenyl)-

生成物 1

HCID 30599181H-Purine, 8-(2-methoxy-4-(methylsulfinyl)phenyl)-

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6422Trifluoroacetic acid溶媒HCID 11430Potassium Carbonate溶媒

反応条件

温度
5 °C

実験手順

An amount of 2.27 g of 8-(2-methoxy-4-methylmercaptophenyl)-purine was dissolved in 20 ml of trifluoro acetic acid, and 1.2 ml of 30% hydrogen peroxide were added under cooling to 5° C. After stirring for 3 hours at room temperature and for 0.5 hours at 30° C., the reaction mixture was diluted with water and neutralized with potassium carbonate, and the residue obtained after evaporation was extracted with hot ethanol. The product obtained was purified over silicagel (eluate: methylene chloride/ethanol in a volume ratio of 19:1).

後処理

  1. customthe residue obtained
  2. customafter evaporation
  3. extractionwas extracted with hot ethanol
  4. customThe product obtained
  5. customwas purified over silicagel (eluate: methylene chloride/ethanol in a volume ratio of 19:1)

出典と根拠

ORDレコード
ord-507cfd61a71a486b945608256e6bcdcb
出典データセット
uspto-grants-1981_11
特許番号
US04299834

反応ノート

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