(R)-1-Cbz-2-(aminocarbonyl)piperidine → 2-Piperidinecarboxamide, (R)-

HRID 1155088ノート

反応式

HRID 1155088 の反応式
[N:1]1(C(OCC2C=CC=CC=2)=O)[CH2:9][CH2:8][CH2:7][CH2:6][C@@H:2]1[C:3]([NH2:5])=[O:4]>CO.[Pd]>[NH:1]1[CH2:9][CH2:8][CH2:7][CH2:6][C@@H:2]1[C:3]([NH2:5])=[O:4]

参加物

4

反応物 1

HCID 27281977(R)-1-Cbz-2-(aminocarbonyl)piperidine

生成物 1

HCID 70621612-Piperidinecarboxamide, (R)-収率 90%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

3.93 g (15 mmoles) of Z-D-Pip-NH2 are dissolved in 75 ml of methanol, 0.5 g of a 10% palladium-on-carbon catalyst are added, and hydrogen is bubbled through the mixture for one hour. The catalyst is filtered off, the filtrate is evaporated, and the residue is triturated with ether. 1.70 g (90%) of H-D-Pip-NH2 are obtained: m.p.: 161°-163° C., Rf4 =0.10, [α]D25 =+31.0° (c=1%, in methanol).

後処理

  1. customhydrogen is bubbled through the mixture for one hour
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate is evaporated
  4. customthe residue is triturated with ether

出典と根拠

ORDレコード
ord-7dd3a3e75d6742c6a4f17365b3891bef
出典データセット
uspto-grants-1981_11
特許番号
US04299821

反応ノート

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