Hydrochloric Acid → 4(2-Chlorophenyl)phenacyl chloride

HRID 1155283

反応式

HRID 1155283 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[Cl:18][CH2:19][C:20](Cl)=[O:21].Cl>C(Cl)Cl>[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:13]=[CH:14][C:15]([C:20](=[O:21])[CH2:19][Cl:18])=[CH:16][CH:17]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 2492662-ChlorobiphenylHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 205617034(2-Chlorophenyl)phenacyl chloride収率 90.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

293.7 g (2.2 mols) of aluminium chloride are introduced in portions to a solution of 377 g (2 mols) of 2-chlorobiphenyl in 160 ml (2 mols) of chloroacetyl chloride and 1,000 ml of methylene chloride. After 18 hours, the reaction mixture is poured onto ice and hydrochloric acid. The organic phase is seperated off, washed, dried over sodium sulphate and concentrated in vacuo by distilling off the solvent. The oil which remains is purified by distillation. 478.7 g (90% of theory) of 4(2-chlorophenyl)phenacyl chloride of melting point 47° C. are obtained.

後処理

  1. customThe organic phase is seperated off
  2. washwashed
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated in vacuo
  5. distillationby distilling off the solvent
  6. distillationThe oil which remains is purified by distillation

出典と根拠

ORDレコード
ord-ccd0f74643d54f44a9896a5ebe12eec2
出典データセット
uspto-grants-1981_11
特許番号
US04301166

関連ノート

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