Hydrochloric Acid → 2-(Acetoxymethyl)benzenesulfonamide
反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10].[C:13]([O-:16])(=[O:15])[CH3:14].[K+].Cl>O>[C:13]([O:16][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10])(=[O:15])[CH3:14]参加物
5
実験手順
A mixture of 2-(chloromethyl)benzenesulfonamide (2.00 g), potassium acetate (6.0 g) and water (75 ml) was heated to reflux for 1.5 hour. The pH was adjusted to ca. 5.0 by addition of hydrochloric acid and the chilled mixture was filtered to give 1.05 of of shiny white solid, m.p. 131°-133°. 'H NMR δ(CD3)2CO 8.00-7.83 (M), 7.60-7.25 (M), 6.55 (brd s), 5.47 (s), 2.97 (brd s), 2.10 (s), consistent with the assigned structure.
後処理
- temperaturewas heated
- temperatureto reflux for 1.5 hour
- filtrationthe chilled mixture was filtered
- customto give 1.05 of of shiny white solid, m.p. 131°-133°
出典と根拠
- ORDレコード
- ord-439f86cf23e941daa85e51b148807256
- 出典データセット
- uspto-grants-1982_06
- 特許番号
- US04332611
反応ノート
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