Thionyl Chloride → HCID 178522662、化合物

反応式

[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:15]=[C:14]([C:16]([OH:18])=O)[CH:13]=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].S(Cl)(Cl)=O.[NH2:23][C:24]1[NH:28][N:27]=[N:26][N:25]=1>>[NH:25]1[C:24]([NH:23][C:16]([C:14]2[CH:13]=[CH:12][CH:11]=[C:10]([C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=3)[N:15]=2)=[O:18])=[N:28][N:27]=[N:26]1

参加物

反応物 3

HCID 24386Thionyl Chloride

HCID 128111286-(3-Nitrophenyl)pyridine-2-carboxylic acid

HCID 178509299HCID 178509299、化合物

生成物 1

HCID 178522662HCID 178522662、化合物収率 96.1%

実験手順

In the same manner as described in Example 13-(1), 6-(3-nitrophenyl)-2-pyridinecarboxylic acid (4.0 g), thionyl chloride (12 ml) and 5-aminotetrazole (1.54 g) are reacted to give N-(5-tetrazolyl)-6-(3-nitrophenyl)-2-pyridinecarboxamide (4.9 g). M.P. 275°-279° C. (decomp.)