Allyl bromide → 3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-1-N-(2-propenyl)-1,2,5,6-tetrahydropyridine

A mixture of 1.0 g. (3.32 mmoles) of 3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-1,2,5,6-tetrahydropyridine, 539 mg. (3.90 mmoles) of anhydrous potassium carbonate and 401 mg. (3.32 mmoles) of allyl bromide in 23 ml. of ethanol is heated at reflux for 23 hours. The reaction mixture is concentrated under reduced pressure and the residue dissolved in 250 ml. of saturated sodium bicarbonate and 200 ml. of dichloromethane. The organic extract is washed once with 100 ml. of saturated sodium chloride, dried over magnesium sulfate and evaporated to an oil. The oil is purified via column chromatography on 125 g. of silica gel eluted with 5% methanol-dichloromethane to yield 372 mg. (29%) of 3-[4-(1,1-dimethylheptyl)-2-allyloxyphenyl]-1-N-(2-propenyl)-1,2,5,6-tetrahydropyridine as an oil and 247 mg. (22%) of the title compound, M.P. 109°-110° C. (from ether-pentane).

1. additionA mixture of 1.0 g
2. temperatureat reflux for 23 hours
3. concentrationThe reaction mixture is concentrated under reduced pressure
4. dissolutionthe residue dissolved in 250 ml
5. extractionThe organic extract
6. washis washed once with 100 ml
7. dry with materialof saturated sodium chloride, dried over magnesium sulfate
8. customevaporated to an oil
9. customThe oil is purified via column chromatography on 125 g
10. washof silica gel eluted with 5% methanol-dichloromethane
11. customto yield 372 mg

ORDレコード

ord-3c7356ef96cc49a690b48dfa58a4c98a

出典データセット

uspto-grants-1982_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04332942