Imidazo-[1,2-a]-quinoline-2-methanol → Imidazo[1,2-a]quinoline-2-carbaldehyde

HRID 1155996ノート

反応式

HRID 1155996 の反応式
[CH:1]1[N:5]2[C:6]3[C:11]([CH:12]=[CH:13][C:4]2=[N:3][C:2]=1[CH2:14][OH:15])=[CH:10][CH:9]=[CH:8][CH:7]=3>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[CH:1]1[N:5]2[C:6]3[C:11]([CH:12]=[CH:13][C:4]2=[N:3][C:2]=1[CH:14]=[O:15])=[CH:10][CH:9]=[CH:8][CH:7]=3

参加物

4

反応物 1

HCID 13770452Imidazo-[1,2-a]-quinoline-2-methanol

生成物 1

HCID 13770453Imidazo[1,2-a]quinoline-2-carbaldehyde収率 81.8%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

A mixture of 4.2 g of imidazo-[1,2-a]-quinoline-2-methanol, 16.0 g of manganese dioxide and 11 ml of chloroform was refluxed for 4 hours and was then cooled overnight. The mixture was filtered through cellulose powder and the filter was washed with chloroform. The filtrate was evaporated to dryness under reduced pressure and the residue was triturated with diethyl ether to obtain 3.4 g of imidazo-[1,2-a]-quinoline-2-carboxaldehyde in the form of needles melting at 184°-185° C. after crystallization from an etherchloroform mixture.

後処理

  1. temperaturewas refluxed for 4 hours
  2. temperaturewas then cooled overnight
  3. filtrationThe mixture was filtered through cellulose powder
  4. washthe filter was washed with chloroform
  5. customThe filtrate was evaporated to dryness under reduced pressure
  6. customthe residue was triturated with diethyl ether

出典と根拠

ORDレコード
ord-6fdf767be5064c9ab09ed1d714ac3f93
出典データセット
uspto-grants-1982_06
特許番号
US04333934

反応ノート

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