Piperidine, 1-methyl-4-(4-nitrophenoxy)-4-phenyl- → Piperidine, 4-(p-aminophenoxy)-1-methyl-4-phenyl-

HRID 1156028

反応式

HRID 1156028 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:3]1>C(O)C.[Pt]>[NH2:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][C:5]2([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)=[CH:16][CH:17]=1

参加物

4

反応物 1

HCID 3060390Piperidine, 1-methyl-4-(4-nitrophenoxy)-4-phenyl-

生成物 1

HCID 3060392Piperidine, 4-(p-aminophenoxy)-1-methyl-4-phenyl-収率 74.4%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 702Ethanol溶媒

実験手順

51 g of 1-methyl-4-(4-nitrophenoxy)-4-phenylpiperidine are dissolved in 1.5 liters of ethanol and are hydrogenated under a hydrogen pressure of 1 atmosphere in the presence of platinum. The catalyst is filtered off, the filtrate is concentrated to 300 ml and crystals (which have separated out) are collected. 34.3 g of the title compound of m.p. 173° to 174° C. are obtained by successive concentration of the filtrate.

後処理

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated to 300 ml and crystals (which
  3. customhave separated out)
  4. customare collected

出典と根拠

ORDレコード
ord-8ad115a3f6d441419d4866e6503e5fc5
出典データセット
uspto-grants-1982_06
特許番号
US04333942

関連ノート

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