Hydrochloric Acid → 4-Amino-3-fluorobenzenepropanoic acid

HRID 1156139ノート

反応式

HRID 1156139 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[N+:13]([O-])=O)[CH:5]=[CH:6][C:7]([OH:9])=[O:8].Cl.[H][H]>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[NH2:13])[CH2:5][CH2:6][C:7]([OH:9])=[O:8]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 542673383-(3-Fluoro-4-nitrophenyl)-2-propenoic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 205364634-Amino-3-fluorobenzenepropanoic acid

試薬・触媒・溶媒 2

HCID 702Ethanol触媒HCID 23938Palladium触媒

実験手順

A mixture of 5.0 g. of 3-fluoro-4-nitrocinnamic acid and 100 mg. of 10% palladium-on-carbon in 200 ml. of ethanol containing 5 drops of 5.5 N ethanolic hydrogen chloride is treated with hydrogen in a Parr apparatus at room temperature for 3 hours. The mixture is then filtered through Celite and the filtrate is concentrated, affording 3-fluoro-4-aminohydrocinnamic acid.

後処理

  1. additionA mixture of 5.0 g
  2. filtrationThe mixture is then filtered through Celite
  3. concentrationthe filtrate is concentrated

出典と根拠

ORDレコード
ord-1e8f24fa8e5f4c26a893336980ae12ce
出典データセット
uspto-grants-1982_06
特許番号
US04333940

反応ノート

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