Boron trifluoride etherate → HCID 20536450、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[NH2:13])[CH2:5][CH2:6][C:7]([OH:9])=[O:8].B(F)(F)F.[CH3:18][CH2:19]OCC.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[NH2:13])[CH2:5][CH2:6][C:7]([O:9][CH2:18][CH3:19])=[O:8]参加物
5
実験手順
A solution of 3-fluoro-4-aminohydrocinnamic acid in 100 ml. of absolute ethanol containing 16 ml. of boron trifluoride etherate is heated to reflux for 48 hours. The solution is then cooled, poured into 5% aqueous sodium carbonate and extracted with methylene chloride. Evaporation of the organic extracts yields ethyl 3-fluoro-4-aminohydrocinnamate. CL 176. 3-Fluoro-4-(hexadecylamino)hydrocinnamic acid
後処理
- temperatureto reflux for 48 hours
- temperatureThe solution is then cooled
- extractionextracted with methylene chloride
- customEvaporation of the organic extracts
出典と根拠
- ORDレコード
- ord-7db1135f1b0440cda0292e39a700b975
- 出典データセット
- uspto-grants-1982_06
- 特許番号
- US04333940
反応ノート
読み込み中…