Thionyl Chloride → HCID 13476542、化合物
反応式
O[CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[NH:6][C:5]1=[O:15].S(Cl)([Cl:18])=O>>[Cl:18][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[NH:6][C:5]1=[O:15]参加物
3
実験手順
A mixture of 3.6 parts of 1-(2-hydroxyethyl)-2,4(1H,3H)-quinazolinedione and 40 parts of thionyl chloride is stirred and refluxed overnight. The reaction mixture is allowed to cool to room temperature. The precipitated product is filtered off, washed with 2,2'-oxybispropane and dried, yielding 3.4 parts (86%) of 1-(2-chloroethyl)-2,4-(1H,3H)-quinazolinedione; mp. 215.3° C.
後処理
- temperaturerefluxed overnight
- filtrationThe precipitated product is filtered off
- washwashed with 2,2'-oxybispropane
- customdried
出典と根拠
- ORDレコード
- ord-c5da8d98a7164fa885d9ed1288adb209
- 出典データセット
- uspto-grants-1982_06
- 特許番号
- US04335127
反応ノート
読み込み中…