Hydrogen Bromide → (4-Piperidinyl)(2-thienyl)methanone hydrobromide
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH:8]1[CH2:13][CH2:12][N:11](C(OCC)=O)[CH2:10][CH2:9]1)=[O:7].[BrH:19]>O>[BrH:19].[NH:11]1[CH2:12][CH2:13][CH:8]([C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[O:7])[CH2:9][CH2:10]1参加物
4
実験手順
A mixture of 20 parts of ethyl 4-(2-thienylcarbonyl)-1-piperidinecarboxylate and 120 parts of hydrobromic acid solution 48% in water is stirred and refluxed for 2 hours. The reaction mixture is cooled and the precipitated product is filtered off. It is washed with 2-propanol and dried, yielding 17 parts (85%) of (4-piperidinyl) (2-thienyl)methanone hydrobromide.
後処理
- temperaturerefluxed for 2 hours
- temperatureThe reaction mixture is cooled
- filtrationthe precipitated product is filtered off
- washIt is washed with 2-propanol
- customdried
出典と根拠
- ORDレコード
- ord-052abbf73ef946a6b8b8ae7b5de3c00b
- 出典データセット
- uspto-grants-1982_06
- 特許番号
- US04335127
反応ノート
読み込み中…