L-Valine → HCID 13037991、化合物

HRID 1156407

反応式

HRID 1156407 の反応式
[NH2:1][C@H:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4].O1CCCC1.[Cl:14][CH2:15][CH2:16][N:17]([N:23]=[O:24])[C:18](N=[N+]=[N-])=[O:19]>C(=O)([O-])[O-].[K+].[K+]>[Cl:14][CH2:15][CH2:16][N:17]([N:23]=[O:24])[C:18]([NH:1][C@H:2]([C:6]([OH:8])=[O:7])[CH:3]([CH3:5])[CH3:4])=[O:19]

参加物

5

反応物 3

HCID 6287L-ValineHCID 8028TetrahydrofuranHCID 10654895N-(2-chloroethyl)-N-nitrosocarbamoylazide

生成物 1

HCID 13037991HCID 13037991、化合物収率 64.3%

試薬・触媒・溶媒 1

HCID 11430Potassium Carbonate溶媒

実験手順

Dissolved in a 5% aqueous potassium carbonate solution was 2.1 g of L-valine, and a tetrahydrofuran solution containing 3.2 g of (2-chloroethyl)-nitrosocarbamoyl azide was added at 0° C. The mixture was stirred for two hours. The reaction solution was washed with ether, neutralized with hydrochloric acid, and extracted with ether to obtain 2.9 g (Yield 64%) of N-{(2-chloroethyl)-nitrosocarbamoyl}-L-valine as a slightly yellow oil.

後処理

  1. additionwas added at 0° C
  2. washThe reaction solution was washed with ether
  3. extractionextracted with ether

出典と根拠

ORDレコード
ord-510809cdb5434556a861e4f912d8465c
出典データセット
uspto-grants-1982_06
特許番号
US04335247

関連ノート

読み込み中…