Methyl iodide → Hexahydro-3a-(m-methoxyphenyl)-1,1-dimethyl-indolinium iodide

HRID 1156550ノート

反応式

HRID 1156550 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]2[N:12]([CH3:18])[CH2:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1.[CH3:19][I:20]>CC(C)=O>[I-:20].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]2[N+:12]([CH3:19])([CH3:18])[CH2:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 12838428Hexahydro-3a-(m-methoxyphenyl)-1-methylindoline

生成物 1

HCID 12838431Hexahydro-3a-(m-methoxyphenyl)-1,1-dimethyl-indolinium iodide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

4.6 g of hexahydro-3a-(m-methoxyphenyl)-1-methylindoline are dissolved in 100 ml of acetone, and the solution is treated with 10 ml of methyl iodide. The mixture is boiled at reflux for 10 hours. Thereafter, the solvent is removed by distillation, and the residue is recrystallized from acetone. The hexahydro-3a-(m-methoxyphenyl)-1,1-dimethyl-indolinium iodide obtained melts at 195°-196° C.

後処理

  1. temperatureat reflux for 10 hours
  2. customThereafter, the solvent is removed by distillation
  3. customthe residue is recrystallized from acetone

出典と根拠

ORDレコード
ord-00ede6a5e2034d25a099d2b8442960eb
出典データセット
uspto-grants-1982_06
特許番号
US04336268

反応ノート

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