1,2-Dichloroethane → 1-Acetyl-4-(2-chloroethyl)piperazine

HRID 1156781

反応式

HRID 1156781 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl:10][CH2:11][CH2:12]Cl.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>CC(C)C(=O)C>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:12][CH2:11][Cl:10])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

参加物

6

反応物 4

HCID 111,2-DichloroethaneHCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 837951-Acetylpiperazine

生成物 1

HCID 132894881-Acetyl-4-(2-chloroethyl)piperazine

試薬・触媒・溶媒 1

HCID 112513-Methyl-2-butanone溶媒

実験手順

1-Acetylpiperazine (1.28 g, 10 mmoles), 1,2-dichloroethane (5 g, 50 mmoles), anhydrous sodium carbonate (2.5 g) and potassium iodide (25 mg) are combined in 40 ml of 3-methyl-2-butanone and refluxed for 16 hours. The reaction mixture is evaporated to dryness in vacuo and the residue distributed between 100 ml of water and 150 ml of methylene chloride. The methylene chloride layer is dried over anhydrous magnesium sulfate and evaporated to dryness to yield 2-(4-acetylpiperazino)-ethyl chloride.

後処理

  1. temperaturerefluxed for 16 hours
  2. customThe reaction mixture is evaporated to dryness in vacuo
  3. dry with materialThe methylene chloride layer is dried over anhydrous magnesium sulfate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-2f249119c35d45fdb3ec9d62df4af31b
出典データセット
uspto-grants-1982_06
特許番号
US04337250

関連ノート

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