Hydrochloric Acid → HCID 13015715、化合物

反応式

C([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[O:15][N:14]=2)=[C:9]([Cl:22])[C:8]=1[Cl:23])C.Cl>C(O)C.[OH-].[Na+]>[O:15]1[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:13]([C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:24])=[O:3])=[C:8]([Cl:23])[C:9]=2[Cl:22])=[N:14]1

参加物

実験手順

To a solution of 6.88 g (0.187 m) of ethyl-4-(1,2-benzisoxazol-3-yl)-2,3-dichlorophenoxyacetate of Example 2D in 70 ml of ethanol, 4 ml of 10 N NaOH is added. The mixture is refluxed for 1 hour. The salt which forms is filtered off, and combined with 250 ml of water at 90° C., giving a suspension. Concentrated HCl is added until the mixture is acidic. The mixture is stirred 1 hour at ambient temperature and the product is filtered off. The crude product is recrystallized from ethanol/H2O and then recrystallized from toluene to give 4.1 g (65%) of pure 4-(1,2-benzisoxazol-3-yl)-2,3-dichlorophenoxyacetic acid, m.p. 166°-167° C.