Hydrochloric Acid → N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acid

HRID 1156855ノート

反応式

HRID 1156855 の反応式
[OH-].[Na+].C(O)C.[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[C:11]([NH:13][C:14]1[C:15](=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[C:16]([O:18]C)=[O:17])=[O:12].Cl>O>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[C:11]([NH:13][C:14]1[C:15](=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[C:16]([OH:18])=[O:17])=[O:12]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 12852881methyl N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilate

生成物 1

HCID 12852880N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acid収率 76.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 20 ml of a 10% aqueous solution of sodium hydroxide and 10 ml of ethanol is added 0.95 g of methyl N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilate and the mixture is stirred at room temperature for 1 hour. The reaction mixture is poured into 100 ml of water and after cooling, hydrochloric acid is added to make the mixture weakly acidic. The precipitated crystals are collected by filtration and recrystallized from ethanol to obtain 0.7 g of N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acid as colorless needles.

後処理

  1. temperatureafter cooling
  2. filtrationThe precipitated crystals are collected by filtration
  3. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-ca415bc9bf2f4638b37f464c410206a9
出典データセット
uspto-grants-1982_06
特許番号
US04337270

反応ノート

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