Sodium Hydroxide → sodium N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilate

HRID 1156860ノート

反応式

HRID 1156860 の反応式
[OH-].[Na+:2].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH:8]=[CH:9][C:10]([NH:12][C:13]1[C:14](=[CH:18][CH:19]=[C:20]([Cl:22])[CH:21]=1)[C:15]([OH:17])=[O:16])=[O:11]>>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH:8]=[CH:9][C:10]([NH:12][C:13]1[C:14](=[CH:18][CH:19]=[C:20]([Cl:22])[CH:21]=1)[C:15]([O-:17])=[O:16])=[O:11].[Na+:2]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 54481802N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilic acid

生成物 1

HCID 70541710sodium N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilate収率 83.8%

実験手順

In 300 ml of an aqueous alcoholic solution (ethanol 1:water 1) containing 0.4 g of sodium hydroxide is added 3.6 g of N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilic acid and the mixture is warmed to be completely dissolved. The solution is concentrated under a reduced pressure, the residue is dissolved in 200 ml of warmed ethanol and to this solution is added 900 ml of ether. The precipitated crystals are collected by filtration and dried under reduced pressure to obtain 3.2 g of sodium N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilate.

後処理

  1. temperaturethe mixture is warmed
  2. dissolutionto be completely dissolved
  3. concentrationThe solution is concentrated under a reduced pressure
  4. dissolutionthe residue is dissolved in 200 ml of warmed ethanol and to this solution
  5. additionis added 900 ml of ether
  6. filtrationThe precipitated crystals are collected by filtration
  7. customdried under reduced pressure

出典と根拠

ORDレコード
ord-72c10026ca324256b03cc1fe68edad40
出典データセット
uspto-grants-1982_06
特許番号
US04337270

反応ノート

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