1-(Benzyloxy)-2-bromo-4-nitrobenzene → 4-Benzyloxy-3-bromophenylamine

HRID 1157155ノート

反応式

HRID 1157155 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][C:10]=1[Br:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.O.Cl.[Fe]>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:10]([Br:18])[CH:11]=1

参加物

6

反応物 1

HCID 220178401-(Benzyloxy)-2-bromo-4-nitrobenzene

生成物 1

HCID 220177374-Benzyloxy-3-bromophenylamine

試薬・触媒・溶媒 4

HCID 313Hydrochloric Acid触媒HCID 23925Iron触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of 1-benzyloxy-2-bromo-4-nitrobenzene (50 mg, 0.16 mmol) in ethanol (5 mL) and H2O (0.5 mL) was added iron (134 mg, 2.43 mmol) and one drop of concentrated HCl. The mixture was refluxed for 6 hrs and filtrated. The filtrate was diluted with ethyl acetate, washed with saturated sodium bicarbonated solution, dried over sodium sulfate and concentrated to afford crude 4-amino-1-benzyloxy-2-bromobenzene.

後処理

  1. temperatureThe mixture was refluxed for 6 hrs
  2. filtrationfiltrated
  3. additionThe filtrate was diluted with ethyl acetate
  4. washwashed with saturated sodium bicarbonated solution
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-de2d28f143f94fd79d2e308c49dda941
出典データセット
uspto-grants-2010_10
特許番号
US07807672B2

反応ノート

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