Tributylamine → Clodronate

HRID 1157346

反応式

HRID 1157346 の反応式
[Na+].[Na+].[Cl:3][C:4]([Cl:13])([P:9](=[O:12])([O-:11])[O-:10])[P:5](=[O:8])([OH:7])[OH:6].C(N(CCCC)CCCC)CCC>>[Cl:13][C:4]([Cl:3])([P:5](=[O:6])([OH:8])[OH:7])[P:9](=[O:10])([OH:11])[OH:12]

参加物

3

反応物 2

HCID 7622TributylamineHCID 73554303Dichloromethylenediphosphonic acid

生成物 1

HCID 25419Clodronate

実験手順

An aqueous solution of dichloromethylenediphosphonic acid disodium salt (1.0 g, 3.46 mmol) was loaded on a column of DOWEX 50WX8-100 ion-exchange resin and eluted with water. Tributylamine (1.65 mL, 6.92 mmol) was added and the mixture was shaken vigorously. The resulting solution was concentrated to dryness and coevaporated with anhydrous DMF three times. The residue was dried under vacuum overnight.

後処理

  1. washeluted with water
  2. concentrationThe resulting solution was concentrated to dryness
  3. customThe residue was dried under vacuum overnight

出典と根拠

ORDレコード
ord-eee9d7e1acb74bf79f8becde6b56a395
出典データセット
uspto-grants-2010_10
特許番号
US07807653B2

関連ノート

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