2-(4-Fluoro-3-methyl-benzylidene)-hexanoic acid → 2-(4-Fluoro-3-methyl-benzyl)-hexanoic acid

HRID 1158123ノート

反応式

HRID 1158123 の反応式
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]=[C:7]([CH2:11][CH2:12][CH2:13][CH3:14])[C:8]([OH:10])=[O:9])=[CH:4][C:3]=1[CH3:17]>CO.[Pd]>[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][CH:7]([CH2:11][CH2:12][CH2:13][CH3:14])[C:8]([OH:10])=[O:9])=[CH:4][C:3]=1[CH3:17]

参加物

4

反応物 1

HCID 686422372-(4-Fluoro-3-methyl-benzylidene)-hexanoic acid

生成物 1

HCID 595125992-(4-Fluoro-3-methyl-benzyl)-hexanoic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 2-(4-Fluoro-3-methyl-benzylidene)-hexanoic acid (0.850 g, 3.600 mmol) in 20 mL of MeOH, was added Pd—C (10 wt % on activated carbon, 0.170 g). After stirring at room temperature under H2 for 16 h, the reaction mixture was filtered through a pad of Celite and washed with MeOH. The filtrate was concentrated under reduced pressure and the crude product was used directly in the next step without further purification. LC-MS: tR=9.3 min; m/z 239 (M+H)+.

後処理

  1. filtrationthe reaction mixture was filtered through a pad of Celite
  2. washwashed with MeOH
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customthe crude product was used directly in the next step without further purification

出典と根拠

ORDレコード
ord-2676037a4820488b90fc49932f2725c2
出典データセット
uspto-grants-2010_10
特許番号
US07807720B2

反応ノート

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