Lithium Hexamethyldisilazide → (R)-3-((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzyloxy)hexanoyl)-4-benzyloxazolidin-2-one

反応式

[F:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([N:15]2[C@H:19]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:18][O:17][C:16]2=[O:27])=[O:14])=[CH:4][C:3]=1[CH3:30].[Li+].C[Si]([N-][Si](C)(C)C)(C)C.[CH3:41][C:42]1[CH:43]=[C:44]([CH:47]=[C:48]([CH3:51])[C:49]=1[F:50])[CH2:45]Br>C1COCC1>[F:50][C:49]1[C:48]([CH3:51])=[CH:47][C:44]([CH2:45][C@H:12]([CH2:11][CH2:10][CH2:9][CH2:8][O:7][CH2:6][C:5]2[CH:28]=[CH:29][C:2]([F:1])=[C:3]([CH3:30])[CH:4]=2)[C:13]([N:15]2[C@H:19]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:18][O:17][C:16]2=[O:27])=[O:14])=[CH:43][C:42]=1[CH3:41]