1,1'-Biphenyl, 3-nitro- → 3-Aminobiphenyl

HRID 1158191

反応式

HRID 1158191 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 164501,1'-Biphenyl, 3-nitro-

生成物 1

HCID 167173-Aminobiphenyl収率 77.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

3-nitrobiphenyl (500 mg, 2.5 mmol) and 10% palladium on carbon (267 mg, 2.5 mmol) were dissolved in methanol (1 mL) and purged with nitrogen and placed under an atmosphere of hydrogen overnight. The reaction mixture was filtered and evaporated to yield 326 mg of the desired amine, which was used directly in Example 12.

後処理

  1. custompurged with nitrogen
  2. filtrationThe reaction mixture was filtered
  3. customevaporated

出典と根拠

ORDレコード
ord-fb8eac53c5df4318868e93e72310194f
出典データセット
uspto-grants-2010_10
特許番号
US07807713B2

関連ノート

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