Thionyl Chloride → 3,4-Difluorophenylacetyl chloride
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[F:8].S(Cl)([Cl:15])=O>ClCCCl>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([Cl:15])=[O:12])[CH:5]=[CH:6][C:7]=1[F:8]参加物
4
実験手順
To (3,4-difluoro-phenyl)-acetic acid (2.0 g) dissolved in 1,2-dichloroethane (5 mL) was added thionyl chloride (5 mL) and the mixture was refluxed for 16 hours under argon. The crude mixture was concentrated in vacuo to furnish 2.2 g (100%) of the title compound as a yellow oil. 1H NMR (500 MHz, CDCl3): 4.10 (s, 2H), 7.00 (m, 1H), 7.11 (m, 1H), 7.17 (m, 1H).
後処理
- temperaturethe mixture was refluxed for 16 hours under argon
- concentrationThe crude mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-c79599bc3fde44aba7e73506a2596dfa
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07812023B2
反応ノート
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