Methyl iodide → 6,7,8,9-Tetrahydro-5H-imidazo[1,2-a]azepine-2-carbaldehyde

温度

23 °C

Thiocaprolactam (6.45 gram, 50 mmol) was dissolved in 400 ml CH2Cl2 and methyl iodide (16 ml, 5 eq) was next added. The mixture was stirred under nitrogen for 18 hrs. Then it was treated with 100 ml potassium carbonate (50%, aq.). The organic layer was then dried over magnesium sulfate. After filtration and concentration 7.3 gram of material was obtained. This material was dissolved 300 ml ethanol and 2.83 gram of ammonium chloride was added. The mixture was refluxed for 1 hr. Then the solvent was removed in vacuo. Half of the material was added 200 ml ethanol and then followed by addition of 1.35 gram (25 mmol) sodium methoxide and 4.8 gram (25 mmol) 2-Bromo-3-isopropoxy-propenal and the mixture was stirred at 23° C. for 2 hrs. Then the solvent was removed and 200 ml chloroform was added along with 10 ml triethyl amine. The mixture was refluxed for 2 hrs and then cooled to 23° C. The reaction media was partitioned between 300 ml DCM and 2×150 potassium carbonate (50%). The organic layer was dried over magnesium sulfate. After filtration and concentration 2.1 gram of oil product was obtained.

1. dry with materialThe organic layer was then dried over magnesium sulfate
2. filtrationAfter filtration and concentration 7.3 gram of material
3. customwas obtained
4. additionwas added
5. temperatureThe mixture was refluxed for 1 hr
6. customThen the solvent was removed in vacuo
7. additionHalf of the material was added 200 ml ethanol
8. stirringthe mixture was stirred at 23° C. for 2 hrs
9. customThen the solvent was removed
10. addition200 ml chloroform was added along with 10 ml triethyl amine
11. temperatureThe mixture was refluxed for 2 hrs
12. customThe reaction media
13. customwas partitioned between 300 ml DCM and 2×150 potassium carbonate (50%)
14. dry with materialThe organic layer was dried over magnesium sulfate
15. filtrationAfter filtration and concentration 2.1 gram of oil product
16. customwas obtained

ORDレコード

ord-e0fb1c651ba84460aebd5b675d97b16a

出典データセット

uspto-grants-2010_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07812014B2