HCID 21941479、化合物 → 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carbaldehyde

HRID 1158926ノート

反応式

HRID 1158926 の反応式
[NH:1]1[N:9]2[CH:4]([O:5][CH2:6][CH:7]=[CH:8]2)[CH2:3][CH:2]1[CH2:10][OH:11]>CCl.O=[Mn]=O>[N:1]1[N:9]2[C:4]([O:5][CH2:6][CH2:7][CH2:8]2)=[CH:3][C:2]=1[CH:10]=[O:11]

参加物

4

反応物 1

HCID 21941479HCID 21941479、化合物

生成物 1

HCID 118471296,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carbaldehyde収率 104.7%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6327Methyl Chloride溶媒

実験手順

To the stirred solution of 2,3-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl-methanol (2.08 g, 13.5 mmol) in 60 ml of CH3Cl was added 9.38 g of MnO2. The suspension was refluxed for 2 hour under a nitrogen atmosphere. The reaction mixture was filtered through a pad of Celite. The filtrate was concentrated to give yellow oil. The product was purified by chromatography. 2.15 g of the product was obtained (78%).

後処理

  1. temperatureThe suspension was refluxed for 2 hour under a nitrogen atmosphere
  2. filtrationThe reaction mixture was filtered through a pad of Celite
  3. concentrationThe filtrate was concentrated
  4. customto give yellow oil
  5. customThe product was purified by chromatography

出典と根拠

ORDレコード
ord-96dcfd0d32cb41eab922adbea7146a22
出典データセット
uspto-grants-2010_10
特許番号
US07812014B2

反応ノート

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