HCID 11845250、化合物 → (4,5,6,7-Tetrahydropyrazolo[1,5-A]pyrazin-2-YL)methanol
反応式
[N+](C1C=CC(COC([N:12]2[CH2:17][CH2:16][N:15]3[N:18]=[C:19]([CH2:21][OH:22])[CH:20]=[C:14]3[CH2:13]2)=O)=CC=1)([O-])=O>[Pd].CO>[N:18]1[N:15]2[CH2:16][CH2:17][NH:12][CH2:13][C:14]2=[CH:20][C:19]=1[CH2:21][OH:22]参加物
4
実験手順
Methanol (150 ml) was added to the mixture of 2-hydroxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid 4-nitrobenzyl ester (Example 25) (2.38 g) and 10% Pd—C (50% wet, 1.19 g). The reaction mixture was stirred for 2 hours under a hydrogen atmosphere. The mixture was filtered and concentrated under reduced pressure. The residue was applied to silica-gel column chromatography, then the column was eluted with 50% methanol in chloroform. The titled compound was obtained as a white solid (1.08 g, 98%).
後処理
- filtrationThe mixture was filtered
- concentrationconcentrated under reduced pressure
- washthe column was eluted with 50% methanol in chloroform
出典と根拠
- ORDレコード
- ord-d363f1aace744453ba5d97ea0c397acc
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07812014B2
反応ノート
読み込み中…