Formamidine acetate → HCID 178435739、化合物

HRID 1159184ノート

反応式

HRID 1159184 の反応式
[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([CH2:13][CH:14]([NH2:17])[CH2:15][NH2:16])=[CH:10][CH:9]=[CH:8]2)[CH3:2].[C:18](O)(=O)C.C(N)=N>CCO>[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([CH2:13][CH:14]1[CH2:15][NH:16][CH:18]=[N:17]1)=[CH:10][CH:9]=[CH:8]2)[CH3:2]

参加物

4

反応物 2

HCID 160693Formamidine acetateHCID 575431993-(8-Ethyl-naphthalen-1-yl)-propane-1,2-diamine

生成物 1

HCID 178435739HCID 178435739、化合物収率 60.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3-(8-ethyl-naphthalen-1-yl)-propane-1,2-diamine (60 mg) in EtOH (6 ml) was treated at r.t. under an argon atmosphere with formamidine acetate (30 mg). The reaction mixture was stirred at r.t. overnight, then concentrated. The crude product was purified by column chromatography (silica gel; eluent: CH2Cl2→CH2Cl2/MeOH 9:1) to give (RS)-4-(8-ethyl-naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole (38 mg) as light yellow gum. MS (ISP): 239.3 ((M+H)+).

後処理

  1. concentrationconcentrated
  2. customThe crude product was purified by column chromatography (silica gel; eluent: CH2Cl2→CH2Cl2/MeOH 9:1)

出典と根拠

ORDレコード
ord-dbb51d7f49384948ad7b6168a2413755
出典データセット
uspto-grants-2010_10
特許番号
US07812047B2

反応ノート

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