Cyclopropylacetylene → 5-(4-Chloro-phenyl)-6-cyclopropylethynyl-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide

反応式

Cl[C:2]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)=[CH:16][C:5]([C:6]([NH:8][C@@H:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]2[OH:15])=[O:7])=[CH:4][N:3]=1.[C:25]([CH:27]1[CH2:29][CH2:28]1)#[CH:26]>>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]([C:17]2[C:2]([C:26]#[C:25][CH:27]3[CH2:29][CH2:28]3)=[N:3][CH:4]=[C:5]([CH:16]=2)[C:6]([NH:8][C@@H:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]2[OH:15])=[O:7])=[CH:19][CH:20]=1

参加物

反応物 2

HCID 138823Cyclopropylacetylene

HCID 866191846-chloro-5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide

生成物 1

HCID 675050165-(4-Chloro-phenyl)-6-cyclopropylethynyl-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide

実験手順

The title compound was synthesized in analogy to Example 112, using 6-chloro-5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide and ethynylcyclopropane as starting materials to yield the product as an off-white solid, MS (ISP) 395.3, 397.2 (M+H)+.

出典と根拠

ORDレコード: ord-dc112c2494ff468c917deca1b6702623
出典データセット: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07812028B2

反応ノート

読み込み中…