(Iodomethyl)cyclopentane → Methyl 3-cyclopentyl-2-(4-methylsulfonylphenyl)propionate

HRID 1159464

反応式

HRID 1159464 の反応式
[Li]CCCC.[CH3:6][O:7][C:8](=[O:20])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][CH:11]=1.[CH:21]1([CH2:26]I)[CH2:25][CH2:24][CH2:23][CH2:22]1>C1COCC1.COC1SC(=O)N(CSP(OC)(OC)=S)N=1>[CH3:6][O:7][C:8](=[O:20])[CH:9]([C:10]1[CH:11]=[CH:12][C:13]([S:16]([CH3:19])(=[O:17])=[O:18])=[CH:14][CH:15]=1)[CH2:26][CH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1

参加物

6

反応物 3

HCID 2762531(Iodomethyl)cyclopentaneHCID 16640928Methyl 2-(4-(methylsulfonyl)phenyl)acetateHCID 178418339Butyllithium

生成物 1

HCID 19261331Methyl 3-cyclopentyl-2-(4-methylsulfonylphenyl)propionate

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒3 回HCID 13709Methidathion溶媒2 回

実験手順

To a solution of diispropylamine (25 mmol, 3.6 mL) in 24 mL of THF and 7.5 mL of methidathion (DMTP) at −78° C. is added n-BuLi (25 mmol, 10 mL, 2.5 M in hexanes) and the mixture stirred for 15 min. 4-Methylsulfonylphenylacetic acid methyl ester (24 mmol, 5.47 g) in 24 mL of THF and 7.5 mL of DMTP is then added dropwise over 30 min and the reaction is stirred for 90 min further. Cyclopentylmethyliodide (28.9 mmol, 6.08 g) in 10 mL of THF is then added dropwise and the reaction is stirred for 1 h at −78° C. before allowing to warm to RT. After 12 h, the reaction is quenched with water, evaporated and then partitioned between ethyl acetate (EtOAc) and brine, and the organic solution is dried and evaporated to afford an oil. The crude material is chromatographed on silica (eluent: 5%→25% EtOAc in hexanes) to afford 3-cyclopentyl-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester.

後処理

  1. stirringthe reaction is stirred for 90 min further
  2. stirringthe reaction is stirred for 1 h at −78° C.
  3. waitAfter 12 h
  4. customthe reaction is quenched with water
  5. customevaporated
  6. custompartitioned between ethyl acetate (EtOAc) and brine
  7. customthe organic solution is dried
  8. customevaporated
  9. customto afford an oil
  10. customThe crude material is chromatographed on silica (eluent: 5%→25% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-d8ef0e9e40c04f8c93c5fde6d48cf5da
出典データセット
uspto-grants-2010_10
特許番号
US07812167B2

関連ノート

読み込み中…