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2-Methoxybenzoyl chloride → N-[3-(3-{2-[(3-fluorophenyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2-(methyloxy)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxybenzoyl chloride | HCID 88969 | — |
| 反応物 | 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-fluorophenyl)-2-pyrimidinamine | HCID 59511403 | — |
| 反応物 | N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide | HCID 59513880 | — |
| 生成物 | N-[3-(3-{2-[(3-fluorophenyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2-(methyloxy)benzamide | HCID 59513869 | — |
反応手順
In a manner analogous to Example 66, the title compound may be obtained by reacting 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-fluorophenyl)-2-pyrimidinamine and 2-methoxybenzoyl chloride. HRMS: calc. C28H20N6OFS calcd for C31H23FN6O2: 530.1867, found: 531.1941 (M+H)+ 507.1403 found 507.1427+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07812022B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-d45021e038d8439fac9324ccb590cf2e |
| 出典メモ | uspto-grants-2010_10 |