2-Chloro-1-(2-methoxyethoxy)-4-nitrobenzene → 3-Chloro-4-(2-methoxyethoxy)aniline

HRID 1159929ノート

反応式

HRID 1159929 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[O:11][CH2:12][CH2:13][O:14][CH3:15]>CCOC(C)=O.C(O)C.[Pt]>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[O:11][CH2:12][CH2:13][O:14][CH3:15])[NH2:8]

参加物

5

反応物 1

HCID 595137122-Chloro-1-(2-methoxyethoxy)-4-nitrobenzene

生成物 1

HCID 64857493-Chloro-4-(2-methoxyethoxy)aniline収率 97.6%

試薬・触媒・溶媒 3

HCID 23939Platinum触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

2-Chloro-1-{[2-(methyloxy)ethyl]oxy}-4-nitrobenzene (1.0 g) was dissolved in a 1:1 solution of EtOAc and ethanol (30 mL). Pt/C (0.15 g of 10% by weight) was added and the resulting mixture was placed under 50 psi of H2 for 16 h. The reaction was then filtered through celite and the resulting organics were concentrated in vacuo to obtain 0.85 g of the compound. 1H NMR (300 MHz, DMSO-d6): δ 6.88 (d, 1H), 6.66 (m, 1H), 6.50 (m, 1H), 4.00 (m, 2H), 3.63 (m, 2H), 3.33 (s, 3H).

後処理

  1. filtrationThe reaction was then filtered through celite
  2. concentrationthe resulting organics were concentrated in vacuo

出典と根拠

ORDレコード
ord-35b927438199451f9f1267fdd9271980
出典データセット
uspto-grants-2010_10
特許番号
US07812022B2

反応ノート

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