Hydrochloric Acid → 3-amino-3-benzyldihydrofuran-2(3H)-one

HRID 1160180ノート

反応式

HRID 1160180 の反応式
[CH2:1]([C:8]1([N:14]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:12][CH2:11][O:10][C:9]1=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO.C1COCC1>[NH2:14][C:8]1([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:12][CH2:11][O:10][C:9]1=[O:13]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 866323393-benzyl-3-[(diphenylmethylene)amino]dihydrofuran-2(3H)-one

生成物 1

HCID 140831243-amino-3-benzyldihydrofuran-2(3H)-one

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-benzyl-3-[(diphenylmethylene)amino]dihydrofuran-2(3H)-one (5.67 g, 15.95 mmol) in MeOH (50 mL) and THF (50 mL) was added 6N HCl (5.3 mL, 32 mmol). After 5 min stirring at RT, the reaction mixture was concentrated in vacuo, diluted with water and benzophenone was extracted with diethyl ether (3×). The aqueous layer was basified to pH 10 with 6N NaOH, extracted with DCM (×2), dried over sodium sulfate and concentrated in vacuo to give 3-amino-3-benzyldihydrofuran-2(3H)-one as a colorless oil, which was carried as is in the next step.

後処理

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. additiondiluted with water and benzophenone
  3. extractionwas extracted with diethyl ether (3×)
  4. extractionextracted with DCM (×2)
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-2b6f8d85bea242548bed64faff1ae22a
出典データセット
uspto-grants-2010_10
特許番号
US07816378B2

反応ノート

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