Water → 5-Bromo-2-(2H-tetrazol-5-yl)pyridine
反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([Br:9])=[CH:5][N:4]=1)#[N:2].[N-:10]=[N+:11]=[N-:12].[Na+].[Cl-].[NH4+].O>CN(C)C=O>[NH:10]1[C:1]([C:3]2[CH:8]=[CH:7][C:6]([Br:9])=[CH:5][N:4]=2)=[N:2][N:12]=[N:11]1参加物
6
反応条件
- 温度
- 110 °C
実験手順
10 g of 2-cyano-5-bromopyridine prepared in the Preparation example 5 was dissolved in 100 ml of dimethylformamide, 5.33 g of sodiumazide, and 4.4 g of ammonium chloride were added to the solution at room temperature, and the solution was stirred at the temperature of 110° C. for 3 hours for reaction. The reaction mixture was added with water and then was extracted with ethyl acetate. The organic layer, thus separated, was washed with brine, dehydrated, filtrated and concentrated in vacuo thereby to obtain 10.5 g of the title compound. Yield 85%.
後処理
- extractionwas extracted with ethyl acetate
- customThe organic layer, thus separated
- washwas washed with brine
- filtrationfiltrated
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-bf33a5f7539547dfa4ed1db167c346db
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07816379B2
反応ノート
読み込み中…