Thionyl Chloride → 2-(Chloromethyl)-5-(trifluoromethyl)pyridine

HRID 1160221ノート

反応式

HRID 1160221 の反応式
[ClH:1].[F:2][C:3]([F:13])([F:12])[C:4]1[CH:5]=[CH:6][C:7]([CH2:10]O)=[N:8][CH:9]=1.O=S(Cl)[Cl:16]>>[Cl:16][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([F:13])([F:12])[F:2])=[CH:9][N:8]=1.[ClH:1].[Cl:16][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([F:13])([F:12])[F:2])=[CH:9][N:8]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 68694003(5-(trifluoromethyl)pyridin-2-yl)methanol HCl salt

生成物 2

HCID 183617202-(Chloromethyl)-5-(trifluoromethyl)pyridineHCID 686914462-(Chloromethyl)-5-(trifluoromethyl)pyridine hydrochloride

実験手順

The mixture of (5-(trifluoromethyl)pyridin-2-yl)methanol HCl salt (293 mg, 1.4 mmol) and SOCl2 (1.5 ml) was stirred for 10 min. After this time, the solution was concentrated under reduced pressure to give the title compound, 2-(chloromethyl)-5-(trifluoromethyl)pyridine HCl salt.

後処理

  1. concentrationAfter this time, the solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-35205fb3e7a441dd9cf647040934d051
出典データセット
uspto-grants-2010_10
特許番号
US07816357B2

反応ノート

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