Trifluoroacetic acid → (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoic acid hydrochloride

HRID 1160404ノート

反応式

HRID 1160404 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C@H:11]([CH2:20][NH:21][CH:22]([CH3:24])[CH3:23])[CH2:12][C:13]([O:15]C(C)(C)C)=[O:14])[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].C(O)(C(F)(F)F)=O>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C@H:11]([CH2:20][NH:21][CH:22]([CH3:24])[CH3:23])[CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[CH:6][C:7]=1[C:8]#[N:9]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 595162251,1-Dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoate

生成物 1

HCID 68484641(3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoic acid hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoate (0.33 g, 0.94 mmol) in CH2Cl2 (2 mL) was treated with TFA (1 mL) for 1.5 h and the reaction was evaporated thoroughly. The residue was treated with 4N HCl in dioxane (4 mL) and then concentrated (this step was done twice) and the crude product was used directly in the next step.

後処理

  1. customthe reaction was evaporated thoroughly
  2. additionThe residue was treated with 4N HCl in dioxane (4 mL)
  3. concentrationconcentrated (this step

出典と根拠

ORDレコード
ord-3a71f1f5eb4d434a888f348f917d3235
出典データセット
uspto-grants-2010_10
特許番号
US07816395B2

反応ノート

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