Methanol → Methyl 3-amino-5-[methyl(methylsulfonyl)amino]benzoate
反応式
[CH3:1][N:2]([S:16]([CH3:19])(=[O:18])=[O:17])[C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([N+:13]([O-])=O)[CH:12]=1)[C:6]([O:8][CH3:9])=[O:7].CO>[Pd].C(OCC)(=O)C>[NH2:13][C:11]1[CH:10]=[C:5]([CH:4]=[C:3]([N:2]([CH3:1])[S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=1)[C:6]([O:8][CH3:9])=[O:7]参加物
5
実験手順
A mixture of methyl 3-[methyl(methylsulfonyl)amino]-5-nitrobenzoate obtained in Reference Example 95.76 g (20 mmol), 10% Pd/C (50% wet) (1.50 g), methanol (80 mL) and ethyl acetate (80 mL) was stirred at room temperature under hydrogen atmosphere for 1.5 hours. The reaction solution was filtered on Celite and the solvent was evaporated to give 5.11 g (19.8 mmol) of the title compound (yield: 99%).
後処理
- filtrationThe reaction solution was filtered on Celite
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-6d79eb5f11344096a452566a6dec06c5
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07816387B2
反応ノート
読み込み中…