Triethylamine → (R)-N-(1-(5-(5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl)-3-fluoropyridin-2-yl)ethyl)-4,4-difluoro-1-hydroxycyclohexanecarboxamide

反応式

[F:1][C:2]1([F:12])[CH2:7][CH2:6][C:5]([OH:11])([C:8]([OH:10])=O)[CH2:4][CH2:3]1.[Cl:13][C:14]1[CH:15]=[C:16]([F:36])[C:17]([C:30]2[N:31]=[N:32][N:33]([CH3:35])[N:34]=2)=[C:18]([C:20]2[CH:21]=[C:22]([F:29])[C:23]([C@H:26]([NH2:28])[CH3:27])=[N:24][CH:25]=2)[CH:19]=1.C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.C(N(CC)CC)C.C(=O)(O)[O-].[Na+]>CN(C=O)C.O>[Cl:13][C:14]1[CH:15]=[C:16]([F:36])[C:17]([C:30]2[N:31]=[N:32][N:33]([CH3:35])[N:34]=2)=[C:18]([C:20]2[CH:21]=[C:22]([F:29])[C:23]([C@H:26]([NH:28][C:8]([C:5]3([OH:11])[CH2:4][CH2:3][C:2]([F:1])([F:12])[CH2:7][CH2:6]3)=[O:10])[CH3:27])=[N:24][CH:25]=2)[CH:19]=1