Tetrahydrofuran → 5-Methyl-3-phenylhexan-2-one
反応式
CON(C)[C:4](=[O:16])[CH:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][CH:7]([CH3:9])[CH3:8].[CH2:18]1COCC1>C[Mg]Br>[CH3:8][CH:7]([CH3:9])[CH2:6][CH:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4](=[O:16])[CH3:18]参加物
4
実験手順
To a solution of 75 mg (0.317 mmol) N-methoxy-N-methyl-4-methyl-2-phenylpentanamide in 1 mL dry THF, 0.45 mL 1.4 M methylmagnesium bromide was added. The reaction was stirred for 1 h, quenched with 1.2 N HCl and extracted with EtOAc. The EtOAc solution was washed with brine, dried and concentrated leaving the title compound. 1H NMR: (500 MHz, CDCl3): δ 0.95 (2d, 6H), 1.42 (m, 1H), 1.67 (m, 1H), 1.9 (m, 1H), 2.06 (s, 3H), 3.73 (m, 1H), 7.0-7.4 (m, 5H).
後処理
- customquenched with 1.2 N HCl
- extractionextracted with EtOAc
- washThe EtOAc solution was washed with brine
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a2e647c89b4e4a40a7187421c6f4b0b6
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07816534B2
反応ノート
読み込み中…