Sodium Hydroxide → 4-[1-(4'-Isopropyl-2,6-dimethyl-biphenyl-4-yloxy)-2-methyl-propyl]-benzoic acid

HRID 1160928ノート

反応式

HRID 1160928 の反応式
C[O:2][C:3](=[O:32])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]([O:14][C:15]2[CH:20]=[C:19]([CH3:21])[C:18]([C:22]3[CH:27]=[CH:26][C:25]([CH:28]([CH3:30])[CH3:29])=[CH:24][CH:23]=3)=[C:17]([CH3:31])[CH:16]=2)[CH:11]([CH3:13])[CH3:12])=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[CH:28]([C:25]1[CH:24]=[CH:23][C:22]([C:18]2[C:19]([CH3:21])=[CH:20][C:15]([O:14][CH:10]([C:7]3[CH:8]=[CH:9][C:4]([C:3]([OH:32])=[O:2])=[CH:5][CH:6]=3)[CH:11]([CH3:13])[CH3:12])=[CH:16][C:17]=2[CH3:31])=[CH:27][CH:26]=1)([CH3:29])[CH3:30]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 671535504-[1-(4'-Isopropyl-2,6-dimethyl-biphenyl-4-yloxy)-2-methyl-propyl]-benzoic acid methyl ester

生成物 1

HCID 671535774-[1-(4'-Isopropyl-2,6-dimethyl-biphenyl-4-yloxy)-2-methyl-propyl]-benzoic acid収率 91.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To the solution of isomer 1 of 4-[1-(4′-isopropyl-2,6-dimethyl-biphenyl-4-yloxy)-2-methyl-propyl]-benzoic acid methyl ester (510 mg) in methanol (10 mL) is added sodium hydroxide (5 N aqueous, 2 mL) and stirred for 4 h. The reaction mixture is concentrated and acidified by 5 N HCl (2 mL), extracted with ethyl acetate. Combined organic layers are washed with water and brine, dried over sodium sulfate. Concentration gives the title compound (450 mg) as a white solid.

後処理

  1. concentrationThe reaction mixture is concentrated
  2. extractionextracted with ethyl acetate
  3. washCombined organic layers are washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. concentrationConcentration

出典と根拠

ORDレコード
ord-f980f747b4d94962b1158431822a1914
出典データセット
uspto-grants-2010_10
特許番号
US07816557B2

反応ノート

読み込み中…