(-)-(4-(1-Acetoxy-ethyl)phenyl)-5-decyloxypyrimidine → 2-(4-(1-Hydroxyethyl)phenyl)-5-decyloxypyrimidine

HRID 1161

反応式

HRID 1161 の反応式
C([O:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:15][N:14]=2)=[CH:9][CH:8]=1)[CH3:6])(=O)C>CO.[OH-].[Na+]>[OH:4][CH:5]([C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:15][N:14]=2)=[CH:11][CH:12]=1)[CH3:6]

参加物

4

反応物 1

HCID 19694897(-)-(4-(1-Acetoxy-ethyl)phenyl)-5-decyloxypyrimidine

生成物 1

HCID 214682802-(4-(1-Hydroxyethyl)phenyl)-5-decyloxypyrimidine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

反応条件

温度
30 °C

実験手順

4 g of the above product (-)-(4-(1-acetoxyethyl) phenyl)-5-decyloxypyrimidine was dissolved in a mixture of 50 ml of methanol and 10 ml of a 20% sodium hydroxide solution, stirred at 30° C. for 2 hours and hydrolyzed, and the resulting reaction solution was extracted by adding 200 ml of water and 200 ml of toluene, followed by liquid separation. The obtained organic layer was dried over anhydrous magnesium sulfate and cleared of solvent in vacuo to yield 3.5 g of (-)-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine as a white solid.

後処理

  1. customhydrolyzed, and the resulting reaction solution
  2. extractionwas extracted
  3. additionby adding 200 ml of water and 200 ml of toluene
  4. customfollowed by liquid separation
  5. dry with materialThe obtained organic layer was dried over anhydrous magnesium sulfate

出典と根拠

ORDレコード
ord-01a269bda00c4ee495d089d890ae2b6c
出典データセット
uspto-grants-1998_03
特許番号
US05723610

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