Methanol → 5-Amino-2-(1,3-dihydroxypropan-2-yl)isoquinolin-1(2H)-one

HRID 1161191ノート

反応式

HRID 1161191 の反応式
[OH:1][CH2:2][CH:3]([N:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[N+:16]([O-])=O)[C:7]1=[O:19])[CH2:4][OH:5].CO>[Pd]>[NH2:16][C:12]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:13]=1[CH:14]=[CH:15][N:6]([CH:3]([CH2:2][OH:1])[CH2:4][OH:5])[C:7]2=[O:19]

参加物

4

反応物 2

HCID 887MethanolHCID 595157632-(1,3-Dihydroxypropan-2-yl)-5-nitroisoquinolin-1(2H)-one

生成物 1

HCID 595157945-Amino-2-(1,3-dihydroxypropan-2-yl)isoquinolin-1(2H)-one

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

2-(1,3-dihydroxypropan-2-yl)-5-nitroisoquinolin-1(2H)-one (1.2 g, 0.0045 mol) was stirred with palladium 10% wt. on calcium carbonate (0.1 g, 0.0005 mol) in methanol (100 mL, 2 mol) under hydrogen (balloon) over 1 hr at room temperature. The catalyst was filtered, the filtrate was concentrated to dryness gave light green oil. MS m/z=235.0 (M+1).

後処理

  1. filtrationThe catalyst was filtered
  2. concentrationthe filtrate was concentrated to dryness
  3. customgave light green oil

出典と根拠

ORDレコード
ord-b19a09a297184d689cbac23d448ed8af
出典データセット
uspto-grants-2010_10
特許番号
US07816371B2

反応ノート

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