Methanol → (R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

HRID 1161203ノート

反応式

HRID 1161203 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14])([O-])=O.CO>[Pd].C(OC(=O)C)C>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14]

参加物

5

反応物 2

HCID 887MethanolHCID 59515648(R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

生成物 1

HCID 59515719(R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A round bottom flask was charged with (R)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (5.0 g, 0.018 mol), palladium on charcoal (10%) (0.3 g, 0.003 mol) and methanol (200 mL, 5 mol) and ethylacetate (80 mL). The reaction mixture was stirred under hydrogen (1 atm) at room temperature for 40 minutes. The mixture was filtered over celite, the solvent was removed to yield the product as a light yellow solid. MS m/z=232.3 (M+H).

後処理

  1. filtrationThe mixture was filtered over celite
  2. customthe solvent was removed

出典と根拠

ORDレコード
ord-64195eda6fb0403d95b6686d34fb1398
出典データセット
uspto-grants-2010_10
特許番号
US07816371B2

反応ノート

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