Methanol → (R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

HRID 1161218ノート

反応式

HRID 1161218 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14])([O-])=O.CO>[Pd].CCOC(C)=O>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14]

参加物

5

反応物 2

HCID 887MethanolHCID 59515648(R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

生成物 1

HCID 59515719(R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

Into a round bottom flask was combined (R)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (5.0 g, 0.018 mol), palladium on C (0.3 g, 0.003 mol) and methanol (200 mL, 5 mol) (about 80 mL EtOAc was added to dissolve the reactants). The reaction mixture was stirred under hydrogen balloon at room temperature for 40 min. The mixture was filtered over celite, MeOH was removed and a solid was obtained (4.02 g). MS m/z=232.4 (M+1).

後処理

  1. customInto a round bottom flask was combined
  2. dissolutionto dissolve the reactants)
  3. filtrationThe mixture was filtered over celite, MeOH
  4. customwas removed
  5. customa solid was obtained (4.02 g)

出典と根拠

ORDレコード
ord-ee2380f8ee1148fa91a35ce668e1d8e3
出典データセット
uspto-grants-2010_10
特許番号
US07816371B2

反応ノート

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