Methanol → (R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)-N,3-dimethylbutanamide
反応式
[CH3:1][CH:2]([CH3:22])[C@@H:3]([N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[N+:18]([O-])=O)[C:9]1=[O:21])[C:4]([NH:6][CH3:7])=[O:5].CO>[Pd]>[NH2:18][C:14]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:15]=1[CH:16]=[CH:17][N:8]([C@H:3]([CH:2]([CH3:22])[CH3:1])[C:4]([NH:6][CH3:7])=[O:5])[C:9]2=[O:21]参加物
4
実験手順
(R)-3,N-Dimethyl-2-(5-nitro-1-oxo-1H-isoquinolin-2-yl)-butyramide (1.4 g, 0.0045 mol) was stirred with palladium 10% wt. on calcium carbonate (1.4 g, 0.00068 mol) in methanol (100 mL, 2 mol) under hydrogen (balloon) over 1 h at room temperature. The catalyst was filtered, the filtrate was concentrated to dryness to give a yellow solid. MS m/z 273.9 (M+H)+.
後処理
- filtrationThe catalyst was filtered
- concentrationthe filtrate was concentrated to dryness
- customto give a yellow solid
出典と根拠
- ORDレコード
- ord-0d833d9d1953449eb55ad26ea2bc6b46
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07816371B2
反応ノート
読み込み中…