Ethanol → 4-(5-Amino-1-benzofuran-7-yl)pyridine

HRID 1161984ノート

反応式

HRID 1161984 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:7]2[O:11][CH:10]=[CH:9][C:8]=2[CH:12]=1)([O-])=O.C(O)C.O.NN>O1CCOCC1.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:7]2[O:11][CH:10]=[CH:9][C:8]=2[CH:12]=1

参加物

6

反応物 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 66893958HCID 66893958、化合物2 回

生成物 1

HCID 668930874-(5-Amino-1-benzofuran-7-yl)pyridine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 312751,4-Dioxane溶媒

実験手順

4-(5-Nitro-1-benzofuran-7-yl)pyridine (125 mg, 0.520 mmol; Intermediate 11) was dissolved in 1,4-dioxane (15 mL). After addition of ethanol (20 mL), Raney-nickel (slurry in ethanol; 2 mL) and hydrazine hydrate (4 mL) were added and the mixture was left stirring at room temperature overnight. The product was used directly in the subsequent reaction after filtration through Celite and evaporation of solvent.

後処理

  1. additionwere added
  2. waitthe mixture was left
  3. customThe product was used directly in the subsequent reaction
  4. filtrationafter filtration
  5. customthrough Celite and evaporation of solvent

出典と根拠

ORDレコード
ord-f1e37edef826442c9d9c704dbfd9df1c
出典データセット
uspto-grants-2010_10
特許番号
US07820675B2

反応ノート

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