Hydrazine hydrate (1:1) → 3-Amino-5-bromo-1H-indazole
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[C:7]#[N:8].O.[NH2:12][NH2:13]>O>[NH2:8][C:7]1[C:6]2[C:5](=[CH:4][CH:3]=[C:2]([Br:1])[CH:9]=2)[NH:13][N:12]=1参加物
4
実験手順
A mixture of 5-bromo-2-fluorobenzonitrile (5.00 g, 25 mmol) and hydrazine hydrate (10 mL) was heated at reflux for two hours and then it was allowed to stand at room temperature for two days. The reaction was treated with water (50 mL) and the solids were collected by filtration to give 3-Amino-5-bromo-indazole as a white solid (4.82 g, 91%): mp 165-175° C.; MS [M+H]+ 212, 214.
後処理
- temperaturewas heated
- temperatureat reflux for two hours
- filtrationthe solids were collected by filtration
出典と根拠
- ORDレコード
- ord-48f441ac35d34c3f877041965344fe1b
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07820670B2
反応ノート
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