Methyl 1-benzyl-4-cyclopropylpyrrolidine-3-carboxylate → HCID 68646753、化合物

HRID 1162724ノート

反応式

HRID 1162724 の反応式
[CH3:1][O:2][C:3]([CH:5]1[CH:9]([CH:10]2[CH2:12][CH2:11]2)[CH2:8][N:7](CC2C=CC=CC=2)[CH2:6]1)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH:9]([CH:10]2[CH2:12][CH2:11]2)[CH2:8][NH:7][CH2:6]1)=[O:4]

参加物

4

反応物 1

HCID 68647670Methyl 1-benzyl-4-cyclopropylpyrrolidine-3-carboxylate

生成物 1

HCID 68646753HCID 68646753、化合物収率 85.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

101.2 To a stirred solution of 1.13 g (3RS,4RS)-1-benzyl-4-cyclopropyl-pyrrolidine-3-carboxylic acid methyl ester at r.t. in 10 ml methanol under an argon atmosphere was added 113 mg 10% Pd/C. The mixture was then stirred at r.t. under a hydrogen atmosphere overnight. The catalyst was filtered off and rinsed with methanol. The filtrate was concentrated to leave 630 mg (3RS,4RS)-4-cyclopropyl-pyrrolidine-3-carboxylic acid methyl ester as a light yellow oil. MS170.3 ([M+H]+)

後処理

  1. filtrationThe catalyst was filtered off
  2. washrinsed with methanol
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-326128ba9de0496c9db24ebe38b2f4e5
出典データセット
uspto-grants-2010_10
特許番号
US07820699B2

反応ノート

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