Pinacolone → Pinacolone Semicarbazone

HRID 1162766ノート

反応式

HRID 1162766 の反応式
[CH3:1][C:2](=O)[C:3]([CH3:6])([CH3:5])[CH3:4].Cl.[NH2:9][NH:10][C:11]([NH2:13])=[O:12].C([O-])(=O)C.[Na+]>O>[CH3:1][C:2](=[N:9][NH:10][C:11]([NH2:13])=[O:12])[C:3]([CH3:6])([CH3:5])[CH3:4]

参加物

5

反応物 3

HCID 6416PinacoloneHCID 11236Semicarbazide hydrochlorideHCID 517045Sodium Acetate

生成物 1

HCID 4318256Pinacolone Semicarbazone収率 71%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Pinacolone (10 g, 99.8 mmol) was added to a solution of semicarbazide hydrochloride (11.13 g, 99.8 mmol) and sodium acetate (16.4 g, 199 mmol) in water (60 mL). The mixture was stirred for 17 h at ambient temperature. The white precipitate was filtered and washed with water and diethyl ether. The solid was dried under vacuo at 50° C. to yield the desired product (11.09 g, 70.5 mmol, 71%).

後処理

  1. filtrationThe white precipitate was filtered
  2. washwashed with water and diethyl ether
  3. customThe solid was dried under vacuo at 50° C.

出典と根拠

ORDレコード
ord-a2f123d7b917492a93eeea3892434146
出典データセット
uspto-grants-2010_10
特許番号
US07820707B2

反応ノート

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