Ethanolamine → 2-cyano-N-(2-hydroxyethyl)acetamide
反応式
[C:1]([CH2:3][C:4]([O:6]CC)=O)#[N:2].[NH2:9][CH2:10][CH2:11][OH:12]>CCO>[C:1]([CH2:3][C:4]([NH:9][CH2:10][CH2:11][OH:12])=[O:6])#[N:2]参加物
4
実験手順
To a solution of ethyl 2-cyanoacetate (10 g, 9.41 mL, 88 mmol) in EtOH (100 mL) was added 2-aminoethanol (5.40 g, 5.34 mL, 88 mmol). The mixture was refluxed for 4 h before concentration in vacuo. The mixture was purified on a 100 g Silica column eluting with 0-10% MeOH/DCM. Desired fractions were collected and concentrated to yield the desired product as a brown oil (10.2 g, 79.7 mmol, 90%). The sample was used directly in the next step without any further purification.
後処理
- temperatureThe mixture was refluxed for 4 h before concentration in vacuo
- customThe mixture was purified on a 100 g Silica column
- washeluting with 0-10% MeOH/DCM
- customDesired fractions were collected
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c7b7e49656ed48e390980ec8e9afd00f
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07820707B2
反応ノート
読み込み中…